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The Kingston Crown Court jury had spent two weeks considering a charge of conspiracy to cause an explosion.
Waheed Ali, 25, Sadeer Saleem, 28, and Mohammed Shakil, 32, all from Leeds, admit having known the 7/7 bombers but denied having helped them.
Police said the men helped to find targets in London, but the trio said the trial was guilt by association.
Mr Justice Gross asked the jury if they had reached a verdict on any of the three defendants.
When the foreman said they had not been able to reach verdicts, the judge said the time had come to discharge the jury.
The BBC understands that the Crown Prosecution Service is highly likely to seek a retrial of the three men, the only people ever charged in relation to the attacks.
The trial focused on a trip to London by the three men, which also included two of the eventual suicide bombers.
Prosecutors said the men had effectively carried out a dry run for the attacks by assessing the capital's security during their visit in December 2004.
They alleged the visit was organised by the plot ringleader Mohammad Sidique Khan, who had contacted the men from Pakistan.
Neil Flewitt QC, prosecuting, had told the court that the three were not directly responsible for the explosions that killed 52 and maimed hundreds more.
But he said evidence showed they shared the same objectives as the bombers and knew that some kind of attack was being planned.
The men vehemently denied this, saying that their trip to London had been to allow one of their number to see family and to take in a little tourism.
In tense courtroom scenes, each of the men in turn denounced the prosecution as politically motivated and stressed the bombers' actions had been completely un-Islamic.
(BBC)
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